Therapeutic Response

EGFR positive and Wild type KRAS status confers therapeutic sensitivity to Cetuximab in combination with Irinotecan in patients with Colorectal Adenocarcinoma.

Statements

Source and description
Erbitux (cetuximab) [package insert]. FDA. The U.S. Food and Drug Administration granted approval to cetuximab in combination with irinotecan for the treatment of patients with K-Ras wild-type, EGFR-expressing metastatic colorectal.
Erbitux (cetuximab) [product monograph]. HC. Health Canada approved cetuximab for the treatment of EGFR-expressing K-Ras wild-type metastatic colorectal carcinoma (mCRC) in combination with irinotecan in patients who are refractory to other irinotecan-based chemotherapy regimens.