Therapeutic Response Statement (Sensitivity)

This therapeutic response statement supports the relationship that v::NTRK1 status confers therapeutic sensitivity to Larotrectinib in patients with Any solid tumor.

This statement is based on a regulatory approval from the Health Canada:

VITRAKVI (larotrectinib) is indicated for the treatment of adult and pediatric patients with solid tumours that have a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion without a known acquired resistance mutation.

Citation

Bayer Inc. Vitrakvi (larotrectinib) [product monograph]. Health Canada website. https://pdf.hres.ca/dpd_pm/00076917.PDF. Revised September 2024. Accessed June 2025.