Therapies

Therapies are the individual cancer treatments referenced by propositions in the database. Each therapy has a therapy type defined by the National Cancer Institute: chemotherapy, hormone therapy, immunotherapy, or targeted therapy. The proposition and statement counts include those where the therapy is given as part of a combination.

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Therapy types
Therapy strategies
Name Therapy strategies Therapy type Propositions Statements
Abemaciclib CDK4/6 inhibition Targeted therapy 18 36
Abiraterone acetate Antiandrogen Hormone therapy 17 31
Adagrasib RAS inhibition Targeted therapy 2 2
Afatinib EGFR inhibition Targeted therapy 2 3
Alectinib ALK inhibition Targeted therapy 1 3
Alpelisib PI3K/AKT/mTOR inhibition Targeted therapy 3 6
Amivantamab EGFR inhibition Targeted therapy 6 14
Anastrozole Aromatase inhibition Hormone therapy 13 22
Arsenic trioxide PML::RARA inhibition Targeted therapy 2 4
Asciminib BCR-ABL inhibition Targeted therapy 2 4
Atezolizumab PD-1/PD-L1 inhibition Immunotherapy 12 13
Avapritinib KIT inhibition Targeted therapy 1 1
Avutometinib MEK inhibition, RAF inhibition Targeted therapy 2 2
Azacitidine Hypomethylating agent chemotherapy Chemotherapy 5 10
Belzutifan HIF-2a inhibition Targeted therapy 3 3
Bevacizumab VEGF inhibition Targeted therapy 23 39
Binimetinib MEK inhibition Targeted therapy 3 9
Blinatumomab CD19 inhibition Immunotherapy 2 4
Bosutinib BCR-ABL inhibition Targeted therapy 1 4
Brentuximab vedotin target CD30 antigens Targeted therapy 5 6
Brigatinib ALK inhibition Targeted therapy 1 2
Capecitabine Thymidylate synthase inhibition Chemotherapy 14 18
Capivasertib PI3K/AKT/mTOR inhibition Targeted therapy 23 43
Capmatinib MET inhibition Targeted therapy 2 4
Carboplatin Platinum-based chemotherapy Chemotherapy 30 49
Cemiplimab PD-1/PD-L1 inhibition Immunotherapy 3 4
Ceritinib ALK inhibition Targeted therapy 1 3
Cetuximab EGFR inhibition Targeted therapy 7 14
Cisplatin Platinum-based chemotherapy Chemotherapy 25 37
Cobimetinib MEK inhibition Targeted therapy 4 6
Crizotinib ALK inhibition, MET inhibition, ROS1 inhibition Targeted therapy 4 6
Cyclophosphamide Alkylating chemotherapy Chemotherapy 23 54
Cytarabine DNA Polymerase inhibition Chemotherapy 14 23
Dabrafenib B-RAF inhibition Targeted therapy 9 25
Dacomitinib EGFR inhibition Targeted therapy 2 2
Dasatinib BCR-ABL inhibition Targeted therapy 2 8
Datopotamab deruxtecan Topoisomerase inhibition, Trop-2 directed antibody Targeted therapy 8 8
Daunorubicin Topoisomerase inhibition Chemotherapy 12 21
Defactinib FAK inhibition Targeted therapy 2 2
Dexamethasone Corticosteroid Chemotherapy 1 1
Docetaxel Taxane-based chemotherapy Chemotherapy 8 31
Dordaviprone Protease activation Targeted therapy 1 1
Dostarlimab PD-1/PD-L1 inhibition Immunotherapy 5 6
Doxorubicin Topoisomerase inhibition Chemotherapy 15 32
Durvalumab PD-1/PD-L1 inhibition Immunotherapy 11 17
Elacestrant ER signaling inhibition Hormone therapy 1 1
Enasidenib IDH2 inhibition Targeted therapy 9 9
Encorafenib B-RAF inhibition Targeted therapy 6 15
Ensartinib ALK inhibition Targeted therapy 1 1
Entrectinib ALK inhibition, NTRK inhibition, ROS1 inhibition Targeted therapy 4 8
Enzalutamide Antiandrogen Hormone therapy 24 47
Epirubicin Topoisomerase inhibition Chemotherapy 4 18
Erdafitinib FGFR inhibition Targeted therapy 5 10
Eribulin Tubulin polymerization inhibition Chemotherapy 1 1
Erlotinib EGFR inhibition Targeted therapy 4 4
Everolimus PI3K/AKT/mTOR inhibition Targeted therapy 7 10
Exemestane Aromatase inhibition Hormone therapy 10 16
Fludarabine Antimetabolite Chemotherapy 2 2
Fluorouracil Thymidylate synthase inhibition Chemotherapy 19 37
Fulvestrant Estrogen receptor inhibition Hormone therapy 47 92
Futibatinib FGFR inhibition Targeted therapy 1 1
Gefitinib EGFR inhibition Targeted therapy 3 5
Gemcitabine Antimetabolite Chemotherapy 6 9
Gemtuzumab ozogamicin CD33 inhibition Immunotherapy 2 3
Gilteritinib FLT3 inhibition Targeted therapy 8 16
Goserelin Gonadotropin-releasing hormone (GnRH) agonist Hormone therapy 6 12
Ibrutinib BTK inhibition Targeted therapy 1 1
Idarubicin Topoisomerase inhibition Chemotherapy 1 1
Imatinib Bcr-Abl inhibition, PDGF-R inhibition, c-Kit inhibition Targeted therapy 10 22
Imlunestrant Estrogen receptor inhibition Targeted therapy 1 1
Inavolisib PI3K/AKT/mTOR inhibition Targeted therapy 3 9
Infigratinib FGFR2 inhibition Targeted therapy 1 1
Inotuzumab ozogamicin BCR-ABL inhibition Targeted therapy 1 2
Ipilimumab CTLA-4 inhibition Immunotherapy 8 17
Irinotecan Topoisomerase I inhibition Chemotherapy 3 5
Ivosidenib IDH1 inhibition Targeted therapy 20 35
Lapatinib HER2 inhibition Targeted therapy 4 5
Larotrectinib NTRK inhibition Targeted therapy 3 6
Lazertinib EGFR inhibition Targeted therapy 2 6
Lenalidomide Angiogenesis inhibition Chemotherapy 1 2
Lenvatinib VEGFR inhibition Targeted therapy 1 1
Letrozole Aromatase inhibition Hormone therapy 19 31
Lorlatinib ALK inhibition Targeted therapy 1 3
Margetuximab HER2 inhibition Hormone therapy 4 4
Methotrexate Antifolate Chemotherapy 1 1
Midostaurin FLT3 inhibition Targeted therapy 10 19
Mirvetuximab soravtansine Folate receptor-alpha inhibition Chemotherapy 3 3
Mitoxantrone Topoisomerase inhibition Chemotherapy 1 1
Mobocertinib EGFR inhibition Targeted therapy 1 1
Nab-paclitaxel Taxane-based chemotherapy Chemotherapy 2 3
Neratinib HER2 inhibition Targeted therapy 5 6
Nilotinib BCR-ABL inhibition Targeted therapy 1 7
Niraparib PARP inhibition Targeted therapy 14 20
Nivolumab PD-1/PD-L1 inhibition Immunotherapy 17 29
Olaparib PARP inhibition Targeted therapy 66 124
Olutasidenib IDH1 inhibition Targeted therapy 5 5
Osimertinib EGFR inhibition Targeted therapy 7 22
Oxaliplatin Platinum-based chemotherapy Chemotherapy 15 17
Paclitaxel Taxane-based chemotherapy Chemotherapy 36 60
Palbociclib CDK4/6 inhibition Targeted therapy 25 40
Panitumumab EGFR inhibition Targeted therapy 3 3
Pembrolizumab PD-1/PD-L1 inhibition Immunotherapy 41 57
Pemetrexed Antifolate Chemotherapy 17 31
Pemigatinib FGFR inhibition Targeted therapy 4 6
Pertuzumab HER2 inhibition Targeted therapy 23 63
Ponatinib BCR-ABL inhibition Targeted therapy 3 5
Pralsetinib RET inhibition Targeted therapy 2 2
Prednisolone Corticosteroid Chemotherapy 12 16
Prednisone Corticosteroid Chemotherapy 18 31
Quizartinib FLT3 inhibition Targeted therapy 3 3
Ramucirumab VEGF/VEGFR inhibition Targeted therapy 2 2
Repotrectinib ROS inhibition Targeted therapy 4 5
Revumenib Menin inhibition Targeted therapy 5 5
Ribociclib CDK4/6 inhibition Targeted therapy 15 33
Rituximab CD20 inhibition Immunotherapy 12 15
Rucaparib PARP inhibition Targeted therapy 16 16
Sacituzumab govitecan Topoisomerase inhibition Targeted therapy 5 7
Selpercatinib RET inhibition Targeted therapy 5 7
Sevabertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Sotorasib RAS inhibition Targeted therapy 1 2
Sunvozertinib EGFR inhibition, HER2 inhibition Targeted therapy 1 1
Talazoparib PARP inhibition Targeted therapy 27 52
Taletrectinib NTRK inhibition, ROS1 inhibition Targeted therapy 1 1
Tamoxifen Estrogen receptor inhibition Hormone therapy 3 6
Tazemetostat EZH2 inhibition Targeted therapy 7 7
Telisotuzumab Vedotin MET inhibition Targeted therapy 1 1
Tepotinib MET inhibition Targeted therapy 2 4
Tislelizumab PD-1/PD-L1 inhibition Immunotherapy 16 16
Tovorafenib B-RAF inhibition Targeted therapy 4 4
Trametinib MEK inhibition Targeted therapy 9 26
Trastuzumab HER2 inhibition Targeted therapy 38 82
Trastuzumab deruxtecan HER2 inhibition Targeted therapy 13 19
Trastuzumab emtansine HER2 inhibition Targeted therapy 1 4
Tremelimumab CTLA-4 inhibition Immunotherapy 6 11
Tucatinib HER2 inhibition Targeted therapy 2 3
Vemurafenib B-RAF inhibition Targeted therapy 8 11
Vepdegestrant Estrogen receptor inhibition Targeted therapy 1 1
Vincristine Vinca alkaloid chemotherapy Chemotherapy 9 11
Vinorelbine Vinca alkaloid chemotherapy Chemotherapy 2 3
Vorasidenib IDH1/2 inhibition Targeted therapy 20 40
Zanidatamab ER signaling inhibition Targeted therapy 3 3
Zenocutuzumab NRG1 inhibition Targeted therapy 3 3
Ziftomenib Menin inhibition Targeted therapy 1 1
Zolbetuximab CLDN18.2 inhibition Immunotherapy 2 3
Zongertinib HER2 inhibition Targeted therapy 1 1