BRCA2 oncogenic variants

About

Gene context: BRCA2

Biomarker Type: Somatic Variant

Present: True

Chromosome: 13

Requires Oncogenic: True


Legacy biomarker representation, assumes GRCh37 / hg19 genome build.
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Bevacizumab, Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Olaparib HC
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisolone HC
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisone HC
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Rucaparib FDA
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Rucaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Rucaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Rucaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Enzalutamide, Talazoparib FDA
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Bevacizumab, Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Bevacizumab, Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Bevacizumab, Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Ovarian Epithelial Tumor Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants High-Grade Serous Fallopian Tube Cancer Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Peritoneal Serous Carcinoma Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Olaparib FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisolone FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Olaparib, Prednisone FDA
Sensitivity (+) BRCA2 oncogenic variants Prostate Adenocarcinoma Abiraterone acetate, Niraparib, Prednisone FDA