CHEK2
About
Location: 22q12.1
Mappings
Biomarkers
CHEK2 is involved in the following curated biomarkers.
| Name | Biomarker type | Propositions | Statements |
|---|---|---|---|
| CHEK2 pathogenic variants | Germline Variant | 2 | 2 |
| CHEK2 oncogenic variants | Somatic Variant | 2 | 2 |
Therapeutic response
Precision oncology relationships for therapeutic response involving this gene.
| Type | Biomarker(s) | Cancer type | Therapy(ies) | |
|---|---|---|---|---|
| Sensitivity (+) | CHEK2 pathogenic variants | Prostate Adenocarcinoma | Olaparib | |
| Sensitivity (+) | CHEK2 oncogenic variants | Prostate Adenocarcinoma | Olaparib | |
| Sensitivity (+) | CHEK2 pathogenic variants | Prostate Adenocarcinoma | Enzalutamide, Talazoparib | |
| Sensitivity (+) | CHEK2 oncogenic variants | Prostate Adenocarcinoma | Enzalutamide, Talazoparib |