Biomarkers

Name	Biomarker type	Propositions	Statements
17p deletion	Copy Number (arm level)	1	1
5q deletion	Copy Number (arm level)	1	2
ABL1 p.T315I	Somatic Variant	3	5
AKT1 amplification	Copy Number	3	6
AKT1 somatic variants	Somatic Variant	3	6
ATM oncogenic variants	Somatic Variant	2	3
ATM pathogenic variants	Germline Variant	2	3
ATR oncogenic variants	Somatic Variant	1	1
ATR pathogenic variants	Germline Variant	1	1
BARD1 oncogenic variants	Somatic Variant	1	1
BARD1 pathogenic variants	Germline Variant	1	1
BCR::ABL1	Rearrangement	14	36
BCR::ABL1	Rearrangement	1	1
BRAF p.V600E	Somatic Variant	19	41
BRAF p.V600K	Somatic Variant	11	18
BRAF rearrangements	Rearrangement	1	1
BRCA1 oncogenic variants	Somatic Variant	15	27
BRCA1 pathogenic variants	Germline Variant	21	37
BRCA2 oncogenic variants	Somatic Variant	15	27
BRCA2 pathogenic variants	Germline Variant	21	37
BRIP1 oncogenic variants	Somatic Variant	1	1
BRIP1 pathogenic variants	Germline Variant	1	1
CD117 +	Protein expression	1	3
CD19 +	Protein expression	2	4
CD20 +	Protein expression	12	15
CD22 +	Protein expression	1	2
CD30 +	Protein expression	5	6
CD33 +	Protein expression	2	3
CDK12 oncogenic variants	Somatic Variant	3	3
CDK12 pathogenic variants	Germline Variant	2	2
CHEK1 oncogenic variants	Somatic Variant	1	1
CHEK1 pathogenic variants	Germline Variant	1	1
CHEK2 oncogenic variants	Somatic Variant	2	2
CHEK2 pathogenic variants	Germline Variant	2	2
CLDN18.2 >= 75%	Protein expression	2	3
EGFR Exon 19 (Deletion)	Somatic Variant	10	21
EGFR Exon 20 (Insertion)	Somatic Variant	5	7
EGFR oncogenic variants	Somatic Variant	2	2
EGFR p.L858R	Somatic Variant	10	21
EGFR p.T790M	Somatic Variant	2	3
EGFR positive	Protein expression	3	7
EGFR somatic variants	Somatic Variant	3	4
ER negative	Protein expression	5	6
ER positive	Protein expression	61	106
ERBB2 TKD activating variants	Somatic Variant	1	1
ERBB2 oncogenic variants	Somatic Variant	1	1
ESR1 oncogenic variants	Somatic Variant	2	2
EZH2 p.A692V	Somatic Variant	1	1
EZH2 p.A862G	Somatic Variant	1	1
EZH2 p.Y646C	Somatic Variant	1	1
EZH2 p.Y646F	Somatic Variant	1	1
EZH2 p.Y646H	Somatic Variant	1	1
EZH2 p.Y646N	Somatic Variant	1	1
EZH2 p.Y646S	Somatic Variant	1	1
FANCA oncogenic variants	Somatic Variant	1	1
FANCA pathogenic variants	Germline Variant	1	1
FANCL oncogenic variants	Somatic Variant	1	1
FANCL pathogenic variants	Germline Variant	1	1
FGFR1 rearrangements	Rearrangement	1	1
FGFR2 rearrangements	Rearrangement	1	2
FGFR2::v	Rearrangement	3	4
FGFR3 p.G370C	Somatic Variant	1	2
FGFR3 p.R248C	Somatic Variant	1	2
FGFR3 p.S249C	Somatic Variant	1	2
FGFR3 p.Y373C	Somatic Variant	1	2
FGFR3::TACC3	Rearrangement	1	2
FIP1L1::PDGFRA	Rearrangement	2	3
FLT3 p.D835A	Somatic Variant	2	4
FLT3 p.D835E	Somatic Variant	2	4
FLT3 p.D835H	Somatic Variant	2	4
FLT3 p.D835N	Somatic Variant	2	4
FLT3 p.D835S	Somatic Variant	2	4
FLT3 p.D835V	Somatic Variant	2	4
FLT3 p.D835Y	Somatic Variant	3	4
FLT3 p.I836del	Somatic Variant	1	2
FLT3-ITD	Somatic Variant	6	7
FOLR1 positive	Protein expression	3	3
H3-3A p.K27M	Somatic Variant	1	1
HER2-low	Protein expression	1	2
HER2-negative	Protein expression	94	171
HER2-positive	Protein expression	42	94
HRD	Homologous Recombination	3	3
IDH1 p.R132C	Somatic Variant	7	12
IDH1 p.R132G	Somatic Variant	7	12
IDH1 p.R132H	Somatic Variant	7	12
IDH1 p.R132L	Somatic Variant	7	12
IDH1 p.R132S	Somatic Variant	7	12
IDH2 p.R140G	Somatic Variant	1	1
IDH2 p.R140L	Somatic Variant	1	1
IDH2 p.R140Q	Somatic Variant	1	1
IDH2 p.R140W	Somatic Variant	1	1
IDH2 p.R172G	Somatic Variant	3	5
IDH2 p.R172K	Somatic Variant	3	5
IDH2 p.R172M	Somatic Variant	3	5
IDH2 p.R172S	Somatic Variant	3	5
IDH2 p.R172W	Somatic Variant	3	5
KIT p.D816V	Somatic Variant	1	2
KRAS p.G12C	Somatic Variant	4	5
KRAS p.G12V	Somatic Variant	1	1
MET Exon 14 (Deletion)	Somatic Variant	2	4
MET Exon 14 (Splice Site)	Somatic Variant	2	4
MLH1 oncogenic variants	Somatic Variant	1	1
MLH1 pathogenic variants	Germline Variant	1	1
MRE11 oncogenic variants	Somatic Variant	1	1
MRE11 pathogenic variants	Germline Variant	1	1
MSI-H	Microsatellite Stability	7	10
MSI-L	Microsatellite Stability	1	1
NBN oncogenic variants	Somatic Variant	1	1
NBN pathogenic variants	Germline Variant	1	1
PALB2 oncogenic variants	Somatic Variant	2	2
PALB2 pathogenic variants	Germline Variant	2	2
PD-L1 (CPS) >= 1	Protein expression	13	20
PD-L1 (CPS) >= 10	Protein expression	4	5
PD-L1 >= 1%	Protein expression	9	14
PD-L1 >= 10% TIIC	Protein expression	2	2
PD-L1 >= 50%	Protein expression	4	5
PDGFRA p.D842V	Somatic Variant	1	1
PDGFRA rearrangements	Rearrangement	2	3
PDGFRB rearrangements	Rearrangement	2	3
PIK3CA amplification	Copy Number	1	1
PIK3CA somatic variants	Somatic Variant	9	14
PML::RARA	Rearrangement	1	2
PR negative	Protein expression	5	6
PR positive	Protein expression	58	103
PTEN deletion	Copy Number	3	6
PTEN frameshift variants	Somatic Variant	3	6
PTEN nonsense variants	Somatic Variant	3	6
PTEN splice site variants	Somatic Variant	3	6
RAD51B oncogenic variants	Somatic Variant	1	1
RAD51B pathogenic variants	Germline Variant	1	1
RAD51C oncogenic variants	Somatic Variant	2	2
RAD51C pathogenic variants	Germline Variant	2	2
RAD51D oncogenic variants	Somatic Variant	1	1
RAD51D pathogenic variants	Germline Variant	1	1
RAD54L oncogenic variants	Somatic Variant	1	1
RAD54L pathogenic variants	Germline Variant	1	1
RET oncogenic variants	Somatic Variant	1	2
TMB-H (>= 10 mutations / Mb)	Tumor mutational burden	1	1
TSC1 oncogenic variants	Somatic Variant	2	2
TSC2 oncogenic variants	Somatic Variant	2	2
Wild type ALK	Wild type	27	40
Wild type EGFR	Wild type	27	40
Wild type HRAS	Wild type	2	2
Wild type KRAS	Wild type	7	11
Wild type NRAS	Wild type	2	2
Wild type ROS1	Wild type	2	3
c-Met >= 50%	Protein expression	1	1
dMMR	Mismatch Repair	9	14
pMMR	Mismatch Repair	1	1
t(15;17)	Rearrangement	1	2
t(KMT2A;v)	Rearrangement	4	4
v::ALK	Rearrangement	9	17
v::BRAF	Rearrangement	1	1
v::NRG1	Rearrangement	2	2
v::NTRK1	Rearrangement	3	5
v::NTRK2	Rearrangement	3	5
v::NTRK3	Rearrangement	3	5
v::RET	Rearrangement	6	7
v::ROS1	Rearrangement	4	7