CDK12

About

Location: 17q12

Mappings

HGNC: HGNC:24224

Ensembl: ENSG00000167258

NCBI: 51755

Refseq: NM_016507.4

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Biomarkers

CDK12 is involved in the following curated biomarkers.

Name Biomarker type Propositions Statements
CDK12 pathogenic variants Germline variant 2 2
CDK12 oncogenic variants Somatic variant 3 4

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Organizations Biomarkers Cancer types Therapies
FDA (1) CDK12 oncogenic variants Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) CDK12 pathogenic variants Prostate Adenocarcinoma Olaparib
FDA (1) CDK12 oncogenic variants Prostate Adenocarcinoma Olaparib
FDA (1) HC (1) CDK12 oncogenic variants Prostate Adenocarcinoma Enzalutamide, Talazoparib
FDA (1) CDK12 pathogenic variants Prostate Adenocarcinoma Enzalutamide, Talazoparib