FLT3

About

Location: 13q12.2

Mappings

HGNC: HGNC:3765

Ensembl: ENSG00000122025

NCBI: 2322

Refseq: NM_004119.3

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Biomarkers

FLT3 is involved in the following curated biomarkers.

Name Biomarker type Propositions Statements
FLT3-ITD Somatic variant 5 7
FLT3 p.D835Y Somatic variant 2 4
FLT3 p.D835A Somatic variant 2 4
FLT3 p.D835E Somatic variant 2 4
FLT3 p.D835H Somatic variant 2 4
FLT3 p.D835N Somatic variant 2 4
FLT3 p.D835S Somatic variant 2 4
FLT3 p.D835V Somatic variant 2 4
FLT3 p.I836del Somatic variant 1 2
FLT3 p.I836N Somatic variant

Therapeutic response

Precision oncology relationships for therapeutic response involving this gene.

Organizations Biomarkers Cancer types Therapies
FDA (1) HC (1) FLT3-ITD Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835Y Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835A Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835E Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835H Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835N Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835S Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3 p.D835V Acute Myeloid Leukemia Gilteritinib
FDA (1) HC (1) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835Y Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835A Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835E Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835H Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835N Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835S Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.D835V Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) HC (1) FLT3 p.I836del Acute Myeloid Leukemia Cytarabine, Daunorubicin, Midostaurin
FDA (1) FLT3-ITD Acute Myeloid Leukemia Quizartinib
FDA (1) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Daunorubicin, Quizartinib
FDA (1) FLT3-ITD Acute Myeloid Leukemia Cytarabine, Idarubicin, Quizartinib