Regulatory approval

Published by the Health Canada. Approved

MEKTOVI (binimetinib) is indicated, in combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600 mutation, as detected by a validated test.

This is written in the approval document.

Citation

Pfizer Canada ULC. Mektovi (binimetinib) [product monograph]. Health Canada website. https://pdf.hres.ca/dpd_pm/00083645.PDF. Published February 2026. Accessed April 2026.

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Therapeutic response

Precision oncology relationships for therapeutic response derived from this regulatory approval.

Organizations Biomarkers Cancer types Therapies
HC (1) BRAF p.V600E Melanoma Binimetinib, Encorafenib
HC (1) BRAF p.V600K Melanoma Binimetinib, Encorafenib