BRAF p.V600E

About

Biomarker type: Somatic variant

Gene context: BRAF

HGVS.p: NP_004324.2:p.Val600Glu

Mappings
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Therapeutic response

Precision oncology relationships for therapeutic response involving this biomarker.

Organizations Biomarkers Cancer types Therapies
FDA (1) BRAF p.V600E Melanoma Atezolizumab, Cobimetinib, Vemurafenib
FDA (2) HC (2) BRAF p.V600E Melanoma Binimetinib, Encorafenib
FDA (2) BRAF p.V600E Non-Small Cell Lung Cancer Binimetinib, Encorafenib
FDA (2) HC (1) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib
FDA (1) HC (1) BRAF p.V600E Melanoma Cobimetinib, Vemurafenib
FDA (1) HC (1) BRAF p.V600E Melanoma Dabrafenib
FDA (4) BRAF p.V600E Melanoma Dabrafenib, Trametinib
FDA (2) HC (2) BRAF p.V600E Non-Small Cell Lung Cancer Dabrafenib, Trametinib
FDA (2) BRAF p.V600E Anaplastic Thyroid Cancer Dabrafenib, Trametinib
FDA (2) BRAF p.V600E Any solid tumor Dabrafenib, Trametinib
FDA (2) HC (2) BRAF p.V600E Low-Grade Glioma, NOS Dabrafenib, Trametinib
FDA (1) HC (1) BRAF p.V600E Melanoma Trametinib
FDA (1) HC (1) BRAF p.V600E Melanoma Vemurafenib
FDA (1) BRAF p.V600E Non-Langerhans Cell Histiocytosis/Erdheim-Chester Disease Vemurafenib
FDA (1) BRAF p.V600E Low-Grade Glioma, NOS Tovorafenib
FDA (1) HC (1) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib, Fluorouracil, Oxaliplatin
HC (2) BRAF p.V600E High-Grade Glioma, NOS Dabrafenib, Trametinib
HC (1) BRAF p.V600E Melanoma Pembrolizumab
HC (1) BRAF p.V600E Melanoma Nivolumab
FDA (1) BRAF p.V600E Colorectal Adenocarcinoma Cetuximab, Encorafenib, Fluorouracil, Irinotecan